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Matrine By Hplc in Ta Khmau

Jun 01, 2010 · aim: to prepare rgd-modified long circulating liposome (lcl) loading matrine (rgd-m-lcl) to improve the tumor-targeting and efficacy of matrine.methods: lcl which was prepared with hspc, cholesterol, dspe-peg2000 and dspe-peg-mal was modified with an rgd motif confirmed by high performance liquid chromatography (hplc).the encapsulation efficiency of rgd-m-lcl was also detected by hplc.
The rsd of both the intraday and interday variations was below 1.5% for matrine and tinidazole. the proposed hplc method was validated according to international conference on harmonisation and ...
Subsequently, the mixture was incubated under argon at 60°c for 30 min, and then the generation of rgd-modified long circulating liposome loading matrine (rgd-m-lcl) was complete. some rgd-m-lcl in a drug-lipid ratio of 0.1 was stored at 4°c to determine its stability, particle size and the efficiency of drug-loading.
A rapid, sensitive and selective high-performance liquid chromatography tandem mass spectrometric method (hplc-ms) has been developed and validated for the simultaneous determination of matrine ...

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